Only in the group with vitamin D3 supplementation, it was observed a reduction in undercarboxylated osteocalcin while vitamin K2 increased the carboxylated osteocalcin levels.ĭiabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia as a result of defects in the secretion or action of insulin or both. Individual or combined supplementation with vitamins D3 and K2 significantly decreases the glucose levels and % of functional pancreatic beta cells, while D3 and D3 + K2 treatments also induced a reduction in the uOC/cOC index. Finally, in the vitamins D3 + K2 a significant decrease in glycemia (p = 0.002), percentage of pancreatic beta cells (p = 0.004), and in the uOC/cOC index (p = 0.023) were observed. In vitamin K2 group a significant decrease in glycemia (p = 0.002), HOMA-IR (p = 0.041), percentage of pancreatic beta cells (p = 0.002), and in cOC (p = 0.041) were observed, conversely cOC concentration was found high. ResultsĪfter treatment in the total studied population, a significant decrease in glycemia (p = 0.001), HOMA-IR (Homeostatic model assessment-insulin resistance) (p = 0.040), percentage of pancreatic beta cells (p < 0.001), uOC/cOC index and diastolic blood pressure (p = 0.030) were observed in vitamin D3 group, differences in serum undercarboxylated osteocalcin (p = 0.026), undercarboxylated to carboxylated osteocalcin index (uOC/cOC) (p = 0.039) glucose (p < 0.001) and % of functional pancreatic beta cells (p < 0.001) were demonstrated. The patients were divided into three groups: (a) 1000 IU vitamin D3 + a calcinated magnesium placebo (n = 16), (b) 100 µg of Vitamin K2 + a calcinated magnesium placebo (n = 12), and (c) 1000 IU vitamin D3 + 100 µg vitamin K2 (n = 12). Clinical and laboratory assessment was carried out at the beginning and at the end of the treatment. MethodsĪ double-blind, randomized clinical trial was carried out in 40 patients aged between 30 and 70 years old for 3 months. The objective of this study was to evaluate the effect of vitamin D3 and vitamin K2 supplements alone or in combination on osteocalcin levels and metabolic parameters in patients with T2DM. Patients with type 2 diabetes mellitus (T2DM) are characterized by chronic hyperglycemia as a consequence of decreased insulin sensitivity, which contributes to bone demineralization and could also be related to changes in serum levels of osteocalcin and insulin, particularly when coupled with a deficiency in the daily consumption of vitamins D3 and K2.
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Conrad Stonebanks The Expendables Film 720p Streaming media, The Expendables 3 transparent background PNG clipart size: 1000x562px filesize: 725.57KB.Sylvester Stallone The Expendables 3 Galgo Trench Hale Caesar, Terry Crews transparent background PNG clipart size: 460x1128px filesize: 561.72KB.Mark J.Your may also love these PNG clip art images ©Universal Pictures THE FAN, Wesley Snipes, 1996, (c) TriStar THE FAN, (aka FANATICO), Robert De Niro, right from top: Robert De Niro, Wesley Snipes, 1996, © TriStar BOILING POINT, Dan Hedaya, Wesley Snipes, 1993, (c)Warner Bros. TO WONG FOO THANKS FOR EVERYTHING JULIE NEWMAR, John Leguizamo, Wesley Snipes, Patrick Swayze, 1995. BLADE, Wesley Snipes, 1998 WHITE MEN CAN'T JUMP, Wesley Snipes, Woody Harrelson, 1992, TM and Copyright (c)20th Century Fox Film Corp. TM and Copyright (c) 20th Century Fox Film Corp. DEMOLITION MAN, Wesley Snipes, Sylvester Stallone, 1993, (c) Warner Brothers BLADE: TRINITY, Wesley Snipes, 2004, (c) New Line SUGAR HILL, Wesley Snipes, 1994. ©Warner Brothers MONEY TRAIN, Woody Harrelson, Wesley Snipes, 1995, (c)Columbia Pictures THE FAN, Wesley Snipes, 1996, (c) TriStar SUGAR HILL, Michael Wright, Wesley Snipes (center), Theresa Randle, 1994, TM and Copyright (c)20th Century Fox Film Corp. ©Warner Brothers PASSENGER 57, Wesley Snipes, 1992. Caruso/©Overture Films PASSENGER 57, Wesley Snipes, 1992. BROOKLYN'S FINEST, from left: Don Cheadle, Wesley Snipes, 2009. ph: Phil Bray/©Lionsgate WHITE MEN CAN'T JUMP, Woody Harrelson, Wesley Snipes, 1992. MARSHALS, Tommy Lee Jones, Wesley Snipes, 1998, (c) Warner Brothers WHITE MEN CAN'T JUMP, Woody Harrelson, Wesley Snipes, 1992, TM & Copyright (c) 20th Century Fox Film Corp. In this and other projects, Snipes continued to turn in the thoughtful, detailed character work that had distinguished his career from the beginning. Johnson in the NBC crime drama "The Player" (2015). He also took on his first regular TV role when he was cast as Mr. Marshals" (1998) and "Chaos" (2005), as well as "Expendables 3" (2014) and "Chi-raq" (2015), the latter of which he also produced. Other highlights of Snipes' career included such projects as "U.S. Snipes was equally adept at comedy, most notably in "White Men Can't Jump" (1992), and could transition gracefully from larger-than-life characters like his futuristic villain in "Demolition Man" (1993) to subtler parts like his uncredited turn as a smooth-talking bar patron in "Waiting to Exhale" (1995). Though his athletic prowess made him an ideal action hero in films like "Blade" (1997) and its two sequels, he was also a skilled dramatic actor in films like "New Jack City" (1991), "Jungle Fever" (1991), "The Waterdance" (1992), and "One Night Stand" (1997), which earned him the top acting award at the Venice Film Festival. Wesley Snipes first came to national attention as an actor during the early 1990s, and followed that with a prolific decade of work in which he proved himself to be among the most versatile and popular leading men in Hollywood, qualities he continued to demonstrate as his career moved into the 21st century. 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As Pubert is brought into the world, so too are the Addamses. source: Paramount PicturesĪddams Family Values starts its expansion with Morticia’s childbirth in the hospital. Had the film stayed strictly within the confines of the Addams property, Addams Family Values would have become stifled and stunted. With Addams Family Values, it finds its strength in broadening its exposure further. While their interactions with the outside world are limited, The Addams Family does give further world-building and breadth to the franchise in these moments it allows itself to expand. As they traveled with their expulsion by Fester, they inhabited a small motel in the area. Pinder-Schloss ( Elizabeth Wilson), Tully ( Dan Hedaya), and Gordon (aka Fester) in the first film, The Addams Family briefly saw the Addams gang leave the mansion and venture into the world. Branching Outįollowing the manipulation of Dr. But not just with the arrival of little Pubert, but for the world outside the Addams mansion. As the family interacts with the baby, and we see their continued customs, the world-building here expands. It is as if each of these characters in these moments is speaking to us, welcoming us further into the narrative and the world they encompass.Īs a new Addams joins the ranks, each member of the family reacts differently to Pubert ( Kaitlyn and Kristen Hooper) – the most humorous being Wednesday and Pugsley’s attempts to eliminate the youth given his. It’s in these moments the film is at its cheesiest, but also its more welcoming. Further breaking away from the editing of the original, Addams Family Values also leans more heavily into its editing and filming choices of quickly zooming into close-ups of our characters before they deliver specific lines. 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